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Chrysalis BioTherapeutics Receives Funding from the National Institutes of Health for COVID-19 Therapeutic Development

GALVESTON, Texas–(BUSINESS WIRE)–Chrysalis BioTherapeutics, Inc., a clinical-stage biotechnology company developing regenerative drugs for acute organ injury caused by radiation exposure, announced today that the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health, awarded Chrysalis $912,157 to fund preclinical development of its investigational drug TP508 for SARS-CoV-2 infection. The

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Drug developed by Galveston scientist to be tested for COVID-19 use

GALVESTON A drug developed by an independent biotech firm headquartered in Galveston will be tested for clinical application to problems related to COVID-19, thanks to a $1.5 million grant from the federal government to be released June 1. Chrysalin, or TP508, a regenerative thrombin peptide developed by scientist Darrell Carney, has been tested in human

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Chrysalis BioTherapeutics Receives BARDA Contract for Over $10 million

GALVESTON, Texas, Aug. 27, 2019 /PRNewswire/ — Chrysalis BioTherapeutics, Inc. today announced that the Biomedical Advanced Research and Development Authority (BARDA), an agency of the US government’s Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response, has awarded Chrysalis a contract (HHSO100201900016C) to support the continued development of TP508, rusalatide acetate, as

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Chrysalis BioTherapeutics Granted Orphan Drug Status for TP508

GALVESTON, Texas, Aug. 21, 2019 /PRNewswire/ — Chrysalis BioTherapeutics, Inc. today announced that the US Food and Drug Administration (FDA) Office of Orphan Product Development and the European Medicines Agency (EMA) have granted Orphan Drug Designation (ODD) to the company’s lead compound, TP508 (rusalatide acetate) for the treatment of acute radiation syndrome (ARS). With exposure to high levels of

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Chrysalis Biotherapeutics Initiates $5.45 Million Contract With NIH For Nuclear Countermeasure Development

GALVESTON, Texas, Feb. 7, 2017 /PRNewswire/ — Chrysalis BioTherapeutics, Inc. today announced initiation of a three-year $5.45 million contract with the National Institute of Allergy and Infectious Diseases (NIH-NIAID) to develop TP508 as a countermeasure to increase survival and reduce delayed effects of an accidental or intentional nuclear detonation. “TP508 represents a natural product released at sites of tissue injury

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New drug protects against the deadly effects of nuclear radiation 24 hours after exposure

An interdisciplinary research team led by The University of Texas Medical Branch at Galveston reports a new breakthrough in countering the deadly effects of radiation exposure. A single injection of a regenerative peptide was shown to significantly increase survival in mice when given 24 hours after nuclear radiation exposure. The study currently appears in Laboratory Investigation,

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Chrysalis BioTherapeutics’ TP508 Reverses Radiation-Induced GI Damage

GALVESTON, Texas, Aug. 18, 2015 /PRNewswire/ — Chrysalis BioTherapeutics, Inc. today announced publication of data demonstrating that TP508, the company’s lead drug candidate, activates stem cells in the gastrointestinal (GI) system to prevent breakdown of the intestinal mucosa and decrease ionizing radiation-induced mortality.  The studies, published online at Nature Journals (Laboratory Investigation,  http://www.nature.com/doifinder/10.1038/labinvest.2015.103), showed that a single

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Publications

TP508 Mitigates Radiation Induced GI Damage

Kantara, C., Moya, S.M., Houchen, C.W., Umar, S., Ullrich, R.L., Singh, P. and Carney, D.H. (2015) Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Lab Invest. Aug 17.

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