The TP508 Solution for Nuclear Radiation Exposure

TP508 Mode of Action

a.    Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells.  Olszewska-Pazdrak B, Hart-Vantassell A, Carney DH.  J Vasc Res. 2010;47(3):203-13. doi: 10.1159/000255963. Epub 2009 Nov 6.PMID: 19893317

b.    Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia. Olszewska-Pazdrak B, Carney DH.J Vasc Res. 2013;50(3):186-96. doi: 10.1159/000348250. Epub 2013 Apr 16. PMID: 23594718

c.    Thrombin peptide (TP508) promotes adipose tissue-derived stem cell proliferation via PI3 kinase/Akt pathway. Freyberg S, Song YH, Muehlberg F, Alt E. J Vasc Res. 2009;46(2):98-102. doi: 10.1159/000142727. Epub 2008 Jul 7. PMID: 18607113

d.    Thrombin peptide, TP508, induces differential gene expression in fibroblasts through a nonproteolytic activation pathway. Sower LE, Payne DA, Meyers R, Carney DH. Exp Cell Res. 1999 Mar 15;247(2):422-31. doi: 10.1006/excr.1998.4372 PMID: 10066370

e.    Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. Glenn KC, Frost GH, Bergmann JS, Carney DH. Pept Res. 1988 Nov-Dec;1(2):65-73. PMID: 2856554

TP508 Mode of Action
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