Clinical Trials – Tissue Repair
a. Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study. Fife C, Mader JT, Stone J, Brill L, Satterfield K, Norfleet A, Zwernemann A, Ryaby…
Restoration of Endothelial and Myocardial Function by Injection of TP508
a. TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia. Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L,…
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Mitigation of Radiation-Induced Vascular Damage
a. Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair. Olszewska-Pazdrak B, McVicar SD, Rayavara K, Moya SM, Kantara C, Gammarano C, Olszewska…
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TP508 Mode of Action
a. Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells. Olszewska-Pazdrak B, Hart-Vantassell A, Carney DH. J Vasc Res. 2010;47(3):203-13. doi: 10.1159/000255963. Epub 2009 Nov 6.PMID: 19893317 https://pubmed.ncbi.nlm.nih.gov/19893317/b. Systemic administration…
Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity
Carla Kantara 1, Stephanie M Moya 1, Courtney W Houchen 2, Shahid Umar 3, Robert L Ullrich 4, Pomila Singh 5, Darrell H Carney 1 6 Affiliations expand PMID: 26280221 PMCID: PMC4626368 DOI: 10.1038/labinvest.2015.103 Abstract In recent years, increasing threats of radiation exposure and nuclear disasters have become…
A shutter shock image file of 131812463 with dna like image
Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair
Barbara Olszewska-Pazdrak 1, Scott D McVicar 1, Kempaiah Rayavara 2, Stephanie M Moya 1, Carla Kantara 1 2, Chris Gammarano 1, Paulina Olszewska 1, Gerald M Fuller 2, Laurie E Sower 2, Darrell H Carney 1 2 Affiliations expand PMID: 27388041 PMCID: PMC5009766 DOI: 10.1667/RR14409.1 Abstract There is increasing evidence that radiation-induced damage to endothelial…