Clinical Trials – Tissue Repair
a. Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study. Fife C, Mader JT, Stone J, Brill L, Satterfield K, Norfleet A, Zwernemann A, Ryaby…
Restoration of Endothelial and Myocardial Function by Injection of TP508
a. TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia. Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L,…
A shutter shock image file of 131812463 with dna like image
Mitigation of Radiation-Induced Vascular Damage
a. Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair. Olszewska-Pazdrak B, McVicar SD, Rayavara K, Moya SM, Kantara C, Gammarano C, Olszewska…
A shutter shock image file of 131812463 with dna like image
TP508 Mode of Action
a. Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells. Olszewska-Pazdrak B, Hart-Vantassell A, Carney DH. J Vasc Res. 2010;47(3):203-13. doi: 10.1159/000255963. Epub 2009 Nov 6.PMID: 19893317 https://pubmed.ncbi.nlm.nih.gov/19893317/b. Systemic administration…