a. TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia. Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L, Clubb F, Fuller GM, Carney DH. J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):214-25. doi: 10.1177/ 1074248408321468. PMID: 18757834 https://pubmed.ncbi.nlm.nih.gov/18757834/
b. Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury. Osipov RM, Bianchi C, Clements RT, Feng J, Liu Y, Xu SH, Robich MP, Wagstaff J, Sellke FW.Ann Thorac Surg. 2009 Mar;87(3):786-93. doi: 10.1016/j.athoracsur.2008.12.021.PMID: 19231390 https://pubmed.ncbi.nlm.nih.gov/19231390/
c. Effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes mellitus. Chu LM, Osipov RM, Robich MP, Feng J, Sheller MR, Sellke FW.Circulation. 2010 Sep 14;122(11 Suppl):S162-9. doi: 10.1161/CIRCULATIONAHA.109.928374.PMID: 20837908 https://pubmed.ncbi.nlm.nih.gov/20837908/
d. Effect of thrombin fragment (TP508) on myocardial ischemia-reperfusion injury in hypercholesterolemic pigs. Osipov RM, Robich MP, Feng J, Clements RT, Liu Y, Glazer HP, Wagstaff J, Bianchi C, Sellke FW. J Appl Physiol (1985). 2009 Jun;106(6):1993-2001. doi: 10.1152/japplphysiol.00071.2009. Epub 2009 Apr 16.PMID: 19372304 https://pubmed.ncbi.nlm.nih.gov/19372304/
e. Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine. Oyamada S, Osipov R, Bianchi C, Robich MP, Feng J, Liu Y, Burgess TA, Bell TM, Sheller MR, Sellke FW. J Pharmacol Exp Ther. 2010 Aug;334(2):449-59. doi: 10.1124/jpet.110.166348. Epub 2010 May 11.PMID: 20460385 https://pubmed.ncbi.nlm.nih.gov/20460385/
